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KMID : 1001020160140020069
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Korean Journal of Urological Oncology
2016 Volume.14 No. 2 p.69 ~ p.75
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Is the Expression of p53, c-erb-B2 and Ki-67 Influence the Prognosis of the Non-muscle Invasive Urothelial Bladder Cancer?
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Kang Seok-Hyun
Jung Hyun-Jin
Yang Eun-Kyoung
Park Jae-Shin
Oh Hoon-Kyu
Kim Duk-Yoon
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Abstract
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Purpose: The immunohistochemial markers can be used to predict prognosis more accurately for several cancers. In non-muscle invasive urothelial carcinoma, p53, c-erb-B2 and Ki-67 are applicable. We investigated a retrospective analysis of the relation between the markers and clinical prognostic factors of urothelial bladder cancer.
Materials and Methods: Data from 268 non-muscle invasive urothelial bladder cancer(Ta, T1) patients from one single center were collected. Immunohistochemical evaluation was carried out on 268(p53, c-erb-B2, Ki-67) cases. Clinical prognostic factors are as follows; number of tumor, tumor invasiveness, tumor grade and recurrence. The sum of all positivity of 3 markers was made as a new factor and evaluation of correlation between this factor and prognostic factors was also done. Statistical analysis was done by chi-squares test and Pearson’s correlation test.
Results: Through chi-square test, there were significant relations between all markers and tumor invasiveness(p＜0.001), tumor grade(p＜0.001). Number of tumor is significantly related with Ki-67(p=0.043). Recurrence is related with c-erb-B2(p=0.010) and Ki-67(p=0.043). There was also significant correlations between the sum of the markers and prognostic factors-tumor invasiveness(p＜0,001), tumor grade(p＜0.001) and recurrence(p=0.007).
Conclusions: In this study, evaluated markers were closely related with clinical prognostic factors and may contribute to decision making on risk-assessment and management strategy for non-muscle invasive urothelial bladder cancer. (Korean J Urol Oncol 2016;14:69-75)
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KEYWORD
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Urinary bladder neoplasms, Immunohistochemistry, Risk assessment
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